The Lupus Foundation of America (LFA) reports that “drug-induced lupus accounts for about 10 percent of all lupus cases and is caused by high doses of certain medications. The symptoms of drug-induced lupus are similar to systemic lupus; however, symptoms usually subside when the medications are discontinued.”
The great news is that drug-induced lupus is reversible!
These three drugs cause most cases of drug-induced lupus:
- procainamide (Pronestyl)
- hydralazine (Apresoline)
- quinidine (Quinaglute)
For all the other 35 drugs known to cause drug-induced lupus, the risk is either low, very low or extremely rare. Some of these drugs have only been documented as causing one or two cases of drug-induced lupus.
Drugs Reported to Induce Lupus-Like Disease
|Procainamide (Pronestyl)||high||Propylthiouracil (Propyl-thyracil)||low|
|Disopyramide (Norpace)||very low|
|Propafenone (Rythmol)||very low||Antibiotics|
|Hydralazine (Apresoline)||high||Nitrofurantoin (Macrodantin)||very low|
|Methyldopa (Aldomet)||low||Minocycline (Minocin)||low|
|Enalapril (Vasotec)||very low||Anti-Inflammatories|
|Clonidine (Catapres)||very low||D-Penicillamine (Cuprimine)||low|
|Atenolol (Tenormin)||very low||Sulfasalazine (Azulfidine)||low|
|Labetalol (Normodyne, Trandate)||very low||Phenylbutazone (Butazolidin)||very low|
|Pindolol (Visken)||very low|
|Minoxidil (Loniten)||very low||Diuretics|
|Prazosin (Minipress)||very low||Chlorthalidone (Hygroton)||very low|
|Hydrochlorothiazide (Diuchlor h)||very low|
|Chlorpromazine (Thorazine)||low||Lovastatin (Mevacor)||very low|
|Perphenazine (Trilafon)||very low||Levodopa (Dopar)||very low|
|Phenelzine (Nardil)||very low||Aminoglutethimide (Cytadren)||very low|
|Chlorprothixene (Taractan)||very low||Alpha-interferon (Wellferon)||very low|
|Lithium carbonate (Eskalith)||very low||Timolol eye drops (Timoptic)||very low|
|Phenytoin (Dilantin)||very low|
|Trimethadione (Tridone)||very low|
|Primidone (Mysoline)||very low|
|Ethosuximide (Zarontin)||very low|
Information in the above chart was supplied by the LFA in their article discussing the history, treatment and medical facts about Drug-Induced Lupus.
May 18th – Put on Purple!
Don’t forget to wear purple tomorrow – it will be POP for Lupus Day… Put on Purple!